Point de Suture (2008 - 2010)

The album, Point de Suture, followed suit debuting at Nr.1 with over 100 000 copies sold in its first week in France. The electronic-driven album continues in the vein of Farmer's previous work, featuring a mix of ballads and upbeat, synth-driven pop songs. Farmer's next four singles from the album, "Appelle mon numéro", "Si j'avais au moins...", "C'est dans l'air" and "Sextonik", all became No.1 hits in France, Farmer beating her own record. Farmer then had a record of nine No.1 hits in France, more than any other artist in French music history. It is also the first time that all five singles from her album became No.1 hits. In 2008, Farmer announced a new protégée in the vein of Alizée: Lisa, Farmer's niece. Her lead single, "Drole de creepie", was released in September 2008, produced and written by Boutonnat and Farmer. The song accompanied the hit children's series, Growing Up Creepie, and the video depicts Lisa dressed as Creepie Creecher. Unlike Farmer & Boutonnat's previous side-projects, Lisa is marketed primarily to children. Farmer's sold-out tour began in May 2009 in Nice and ended in September 2009 in Brussels, gathering extremely positive response from the critics. She also gave two concerts at the Stade de France, as well as other concerts in Russia, Belgium and Switzerland. A new live album documenting her 2009 tour, Nr5 on Tour, was released in December 2009 and hit No.1 position in the charts, becoming double- platinum in its first week of release. A DVD of her Stade de France concerts followed on 12 April 2010, becoming instantly Diamond.  

Bleu Noir (2010 - 2011)

In 2010, the media reported that Mylène Farmer would work with Line Renaud and Ben Harper in their respective new releases. After thirty years of absence, Line Renaud released her new album in November 2010, which contains "C'est pas l'heure," a duet with Farmer, written by Farmer and Boutonnat. Also in November, Australian band INXS released the album Original Sin as a tribute to the late Michael Hutchence. Farmer covered "Never Tear Us Apart" with Ben Harper, featuring new lyrics in French written. It was announced surprisingly on 27 September 2010 that Farmer would be releasing a new single "Oui mais... non" to lead her next album. Unlike all the previous musical works by Farmer, Boutonnat was not included in the production or composition. Instead Farmer hired RedOne, known for his work with Lady Gaga to produce and write the music for the single. "Oui mais... non" was released to digital downloading markets on 11 October and hit No.1 on the French charts. Considering the music market crisis, it's her most successful single since 2002. This also makes her the only French singer to have number-one hits in four consecutive decades. The following singles, "Bleu Noir" and "Lonely Lisa", hit the top of the charts too, expanding her record with twelve No.1 singles. The album Bleu Noir was released on 6 December 2010, produced by Farmer, RedOne, Moby and Archive. It entered the French album chart at No.1 and remained at the top for three consecutive weeks. It topped the 9th position in the French 2010 charts, with more than 300,000 copies sold in three weeks. It has sold so far over 600,000 copies, reaching Diamond status, within three months of its release.  

Monkey Me (2012 - 2014)

Farmer's 2nd hits collection entitled 2001-2011 was released in late 2011, featuring all of her hit singles recorded since Les Mots. Early 2012, she said that she was recording an album which was to be released in late 2012. The upcoming new single, "A L'Ombre" will have its radio premiere on 22 October 2012. The single reached number four in French singles chart. The album will be called Monkey Me. Her new tour, Timeless 2013, will debut in September 2013. Nearly 200,000 tickets were sold on the first day. More than 500,000 people in total attended the tour. The live album of the tour was released in December, selling more than 100,000 copies in two weeks. An eponymous film shot in widescreen during the shows in Lyon will premiere in French cinemas on March 27. Mylène Farmer is said to be preparing an album with British rock band Muse.

Interstellaires (2015)

May 15, 2015, Fragile, a photo-book by Sylvie Lancrenon, was published. It included 90 photos of Farmer taken by Lancrenon. In August, a new site was launched, announcing new material from Farmer. The first single to be released was "Stolen Car", a duet with Sting, who originally recorded the song on his 2003 album Sacred Love. The single reached #1 on the French singles chart. On September 18, French magazine Gala announced Farmer's upcoming studio album title as being Interstellaires. It was then officially confirmed on September 16 by Farmer's record label, Polydor on its Facebook page. Another site was then launched with a timer set to the album release date. The album was released in November, becoming Farmer's 12th number one album in France. Farmer signed a new record deal with Sony Music Entertainment, leaving her previous label, Universal. The new record deal confirms that she is releasing a new album.  

Désobéissance (2018 - Present)

January 19 2018, "Rolling Stone" was released and entered the French charts at number one. The video was directed by Carole Denis. A new album was announced for fall. June 22, a duet with LP, "N'oublie pas", was released, also entering the French charts at number one. The song was co-written by LP, and the video, set in Iceland, was directed by Laurent Boutonnat. In June 2019 Mylène began a nine-date concert at the Paris La Défence Arena in Nanterre, her live album titled Live 2019 followed in October and became her 15th number one album which sold over 100.000 copies and reached Platinum status. In 2020 together with Boutonnat, Mylène worked with their new protégé Julia where her album “Passe… comme tu sais on” was released in June. Also a documentary film was released on Amazon Prime Video titled “Mylène Farmer - L’Ultime Création” about her 2019 residency concerts and the behind the scenes preparation. Finally in December a new greatest hits compilation entitled Histoires de Mylène Farmer was released that peaked number two in France.